Protein Details: Store-operated calcium entry regulator STIMATE

Protein ID

ICDB_Pro_1202

Protein Name

Store-operated calcium entry regulator STIMATE

Gene Name

STIMATE; TMEM110

Organism

Homo sapiens (Human)

Length

294 amino acids

AlphaFoldDB

AF-Q86TL2-F1-model_v4.pdb

Function

Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM); called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1; promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions.

Sequence

MQGPAGNASRGLPGGPPSTVASGAGRCESGALMHSFGIFLQGLLGVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVSVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNALMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDVEEDLRRLTPLKPVKKKKHRFGLPV

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Acrofacial Dysostosis;Cincinnati Type and Mixed Liposarcoma

Location

Widely expressed

DOI ID

10.1038/nature04728; 10.1101/gr.2596504; 10.1038/ncb3234; 10.1073/pnas.1521924112

RefSeq

NP_940965.1